Creatine for 12 weeks: adults aged 45 to 65 gained lean mass in a small US trial
In a 12-week trial of 64 adults aged 45-65, creatine (10 g daily) was linked to more lean mass and, with exercise and diet, a bigger drop in body fat.
Longevity research news
Short, plain-English summaries of new research. We link the original source and say how strong the evidence is.
Fish oil and muscle: new review finds no clear benefit for healthy adults
A meta-analysis of placebo-controlled trials found no clear effect of omega-3 on muscle mass or strength in healthy adults, with very low certainty.
Harvard-led team identifies SRSF1 as a candidate 'youthful' gene factor, with lifespan signal in mice
A Nature Aging study looked for factors that shift aged cells to a younger gene profile. SRSF1 stood out, with lifespan signals in small mouse tests.
Large NOPARK trial: nicotinamide riboside did not slow early Parkinson's disease
A 410-person phase 3 trial in JAMA found nicotinamide riboside raised blood NAD but did not improve outcomes in early Parkinson's disease.
Life Biosciences reports first human data for OSK gene therapy ER-100 in glaucoma: three participants
Life Biosciences says its OSK therapy ER-100 was well tolerated in three glaucoma patients to Day 56. Interim, company-reported, uncontrolled data.
NMN for 24 weeks lifted blood NAD+ in older adults, but hearing and fitness tests did not improve
A 24-week placebo-controlled trial in adults aged 65+ found 1,250 mg a day of NMN raised blood NAD+ but did not improve hearing or physical performance.
Small Dutch trial links senolytic combination to liver biopsy improvements in fibrotic MASH
A 31-person trial linked dasatinib plus quercetin to better liver biopsy scores in fibrotic MASH. Small and hypothesis-generating.
Spermidine for 12 months: small brain-scan differences in older adults, but no link to memory
An MRI analysis of 75 older adults found small blood-flow differences in one brain region after 12 months of spermidine, with no link to memory.
Urolithin A for four weeks did not improve blood-vessel function in adults with obesity
A 50-person trial in adults with obesity found 1,000 mg a day of urolithin A for four weeks did not significantly improve blood-vessel function.