Beginner’s guide

NMN Dosage: What Doses Have Human Trials Used?

Updated Nov 3, 2026 · By LongevityBeginners Editorial Team

Updated November 3, 2026. For information only, not medical advice. This guide describes the doses used in studies. It does not recommend a dose. It has no affiliate links, and we do not link to NMN products. Availability varies by country; check local rules before buying. Related: is NMN FDA approved?

Quick answer: the doses human trials have used

Basis: US Google autocomplete, Nov 3, 2026 (“nmn dosage”, “nmn dosage per day”); PMIDs 42514320, 36482258, 35927255.

Human trials have given NMN as fixed daily amounts. Most trials we read used one fixed amount, 250 mg a day. One trial compared 300, 600 and 900 mg a day. A 2026 meta-analysis of 15 trials covered 250 to 2,000 mg a day for 14 days to 24 weeks. No dose has been established as best, and this page does not recommend one.

NMN dosage in human trials

Basis: PMIDs 36482258, 33888596, 35927255, 35479740, 35215405, 38789831, 36797393, 42514320.

This table lists the human trials we read. “Mg a day” means the total daily amount given in the study.

Trial	Who	Amount	Length	What was reported
Yi 2023	80 healthy middle-aged adults	300, 600 or 900 mg a day, once daily	60 days	Blood NAD rose in all NMN groups; well tolerated up to 900 mg
Yoshino 2021	25 postmenopausal women with prediabetes, overweight or obese	250 mg a day	10 weeks	Muscle insulin signaling and insulin-stimulated glucose disposal rose; no adverse events reported
Igarashi 2022	Older men (65 and over)	250 mg a day, once daily	6 or 12 weeks	Blood NAD+ rose; well tolerated; no effect on body composition
Okabe 2022	30 healthy people	250 mg a day (125 mg twice daily)	12 weeks	Blood NAD+ rose; no abnormal lab results or obvious adverse effects
Kim 2022	108 older adults	250 mg a day, once daily	12 weeks	See our timing guide
Morifuji 2024	60 older adults	250 mg a day	12 weeks	No difference on the main stepping test; shorter 4-m walking time with NMN
Katayoshi 2023	36 healthy middle-aged adults	125 mg twice a day (250 mg a day)	12 weeks	Pulse wave velocity tended to fall, but not significantly
Yang 2026 (meta-analysis)	15 trials	250 to 2,000 mg a day	14 days to 24 weeks	No rise in adverse events in 10 trials with safety data

Several studies have company links. Some Yi 2023 authors were employees of two companies (Abinopharm and ABA Chemicals). Mitsubishi Corporation Life Sciences funded Igarashi and supplied the NMN, and employed three of its authors; it also prepared the Okabe supplements and employs one Kim author. Meiji funded Morifuji and employs three of its four authors. Katayoshi’s authors are from DHC Corporation. Yoshino’s authors report patent and licensing ties. Yang 2026 reported no conflict. Igarashi enrolled 42 men, but data from 22 were excluded after a supplier mix-up at the 6-week visit, so 20 finished the 12 weeks.

The dose and schedule for Yoshino come from the full text, because the abstract does not state them.

Does a higher dose do more?

Basis: US Google autocomplete, Nov 3, 2026 (“nmn dosage per day”); PMID 36482258.

One trial tested this directly. In Yi 2023, 80 adults received placebo, 300, 600 or 900 mg once daily for 60 days. Blood NAD rose in every NMN group, and was highest at 600 and 900 mg. The 6-minute walk distance was also longest at 600 and 900 mg. Quality-of-life scores (SF-36) were better in the treated groups, and a measure of insulin resistance (HOMA-IR) did not differ. The authors wrote that clinical efficacy “reaches highest at a dose of 600 mg daily”.

Read that with care. It is one trial of 80 people over 60 days, with company-linked authors. We found no trial that tested these amounts for longer, and we do not read it as a dose to use.

NMN dosage by age and over 50

Basis: US Google autocomplete, Nov 3, 2026 (“nmn dosage by age”, “nmn dosage over 50”); PMIDs 35927255, 35215405.

The trials did not set doses by age. Each gave every participant the same fixed amount. Ages varied by trial: Yi 2023 and Katayoshi 2023 studied middle-aged adults, while Igarashi 2022 (men 65 and over), Kim 2022 and Morifuji 2024 studied older adults, all at 250 mg a day for 12 weeks or less. We found no trial that compared doses between age groups, so there is no age-based dosing to report.

NMN dosage for women and for men

Basis: US Google autocomplete, Nov 3, 2026 (“nmn dosage for women”, “nmn dosage for men”); PMIDs 33888596, 35927255.

Two of the trials focused on one sex. Yoshino 2021 studied 25 postmenopausal women with prediabetes at 250 mg a day for 10 weeks. Igarashi 2022 studied older men at 250 mg a day. The Igarashi authors said they chose men only because hormone changes at menopause might affect results in women, and that it remains to be shown whether NMN works in groups mixed by sex or age. We found no trial that compared doses between women and men.

Dosage by body weight

Basis: US Google autocomplete, Nov 3, 2026 (“nmn dosage by weight”); PMIDs 36482258, 35927255, 33888596.

In the human trials we read, doses were fixed amounts a day (such as 250 mg or 300, 600 and 900 mg), not amounts per kilogram. We found no human NMN trial that set the dose by body weight. Some mouse studies use mg per kg; we do not convert those into human doses.

What a label says vs what trials used

Basis: US Google autocomplete, Nov 3, 2026 (“nmn dosage per day”); NIH Office of Dietary Supplements; PMID 33888596.

The NIH Office of Dietary Supplements says a Supplement Facts label lists the amount per serving, and that the manufacturer suggests the serving size, while a health care provider may decide a different amount is better for you. It also says that more is not always better, and that side effects are more likely at high doses.

For NMN, two things follow. First, compare the amount per serving with the amount per capsule, because they may differ. Second, remember that a trial dose is not a safety limit or a target. Yoshino’s 2021 paper noted that commercial products then ranged from 50 to 150 mg per capsule, so the number of capsules matters. Our guide on how to choose an NMN supplement covers labels and testing. We name no brands.

Safety and the limits of the evidence

Basis: PMIDs 42514320, 42125559, 36482258.

The 2026 meta-analysis found no rise in overall, serious or withdrawal-related adverse events across NMN trials that ran from 14 days to 24 weeks. The authors said larger and longer trials are needed. Yi 2023 reported NMN was well tolerated up to 900 mg a day for 60 days.

EFSA, the European Food Safety Authority, assessed an intended use of up to 300 mg a day in adults, excluding pregnant and lactating women, and concluded NMN is safe under those conditions. That is a scientific opinion about that use, not a recommended dose. Our NMN side effects guide has more. Evidence that any dose improves health is Early.

FAQ

How much NMN should I take per day?

This guide cannot say. It reports what trials used. Most trials we read gave 250 mg a day, one trial compared 300, 600 and 900 mg, and a 2026 meta-analysis covered 250 to 2,000 mg a day. No dose has been established as best. Ask a clinician or pharmacist, especially if you take medicines.

Basis: US Google autocomplete, Nov 3, 2026 (“nmn dosage per day”); PMIDs 42514320, 36482258.

What is the NMN dosage by age?

There is no age-based dosage. The trials gave every participant the same fixed amount. Middle-aged adults received 300 to 900 mg a day in one trial and 250 mg a day in another. Older adults (65 and over in one trial) received 250 mg a day. No trial we read compared doses between age groups.

Basis: US Google autocomplete, Nov 3, 2026 (“nmn dosage by age”); PMIDs 36482258, 36797393, 35927255, 35215405.

What is the NMN dosage for women over 50?

We found no trial that studied a dose specifically for women over 50. The closest is Yoshino 2021, in 25 postmenopausal women with prediabetes who were overweight or obese. They received 250 mg a day for 10 weeks. That describes the study, not a dose to copy, and the trial was small.

Basis: US Google autocomplete, Nov 3, 2026 (“nmn dosage for women”, “nmn dosage over 50”); PMID 33888596 and its full text.

What is the NMN dosage for men?

The main men-only trial is Igarashi 2022. Older men (65 and over) received 250 mg a day, with placebo as the comparison, for 6 or 12 weeks. NMN was well tolerated and blood NAD+ rose. Some muscle-function measures improved nominally, but the authors said larger studies must confirm that. We found no trial comparing doses in men.

Basis: US Google autocomplete, Nov 3, 2026 (“nmn dosage for men”); PMID 35927255.

Is NMN dosage based on body weight?

Not in the human trials we read. They gave fixed daily amounts: 250 mg a day in most, and 300, 600 or 900 mg in one. We found no human NMN trial that set doses per kilogram of body weight. Mouse studies use mg per kg; we do not convert those into human doses.